Figure 6

Structural Simulations of the Prothrombinase Complex. Top and front views of the structural simulations of the prothrombinase complex from three separate groups: Left,[52], Center[53], Right[54]. In the three models the FXa structures (presented in light blue) are based on previously solved crystal structures [PDB ID: 1XKA] [55]. In all three simulations, the FVa domain orientation is based on the crystal structure of bovine inactivated FVa_i (FVa^1-306FVa^LC) solved by Adams et al. [PDB ID: 1SDD] [56]. The FVa^1-306 fragment is presented in purple, the FVa^LC is presented in green, and the hypothetical structure of FVa^307-709, which is based on the homology comparisons to the structure of human ceruloplasmin [PDB ID: 1KCW] [57], is presented in orange. The Arg³⁰⁶ residue is marked in red and encircled by a red circle and with the Arg⁵⁰⁶ residue in black and encircled by a black circle; dashed circles indicate the residue in question is completely masked by a structure from the presented view point.