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Table 2 Equations describing interactions between intact and partially proteolyzed factor Va with factor Xa and prothrombin

From: Modeling of human factor Va inactivation by activated protein C

Eqn

Chemical Expression

koff

kon

kdis

(s-1)

(M-1 s-1)

(s-1)

11

FXa + FVa ← 7-6 → FXaFVa

0.2 a 0.075 b

4 x 108 a

 

1.5 x 108 b

12

FXa + FVai506 ← 8-6 → FXaFVai506

0.4 c

4 x 108 c

 

0.15 b

1.5 x 108 b

13

FXa + FVai306 ← 8-6 → FXaFVai306

0.4 c

4 x 108 c

 

0.15 b

1.5 x 108 b

14

FXa + FVai306/506 ← 8-6 → FXaFVai306/506

0.4 c

4 x 108 c

 

0.15 b

1.5 x 108 b

15

FXaFVai306 -9 → FXa + FVa1-306FVaLC + FVa307-679/709

  

0.0035

16

FXaFVai306/506 -9 → FXa + FVa1-306FVaLC + FVa307-506 + FVa507-679/709

  

0.0035

17

FVa + PT ← 11-10 → FVaPT

70d

1 x 108

 
  1. a Values from previously published studies for mathematical simulations [32, 46].
  2. b Values identified in the current study for mathematical simulations and carried forward through all subsequent mathematical simulations.
  3. c Values are based on relative findings from previously published studies for mathematical simulations [32].
  4. d Initial estimate for FVaPT complex from Tran et al. [39].