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Table 3 Equations describing interactions between catalytically inactive prothrombinase species and prothrombin

From: Modeling of human factor Va inactivation by activated protein C

Eqn

Chemical Expression

koff

kon

kdis

(s-1)

(M-1 s-1)

(s-1)

19

FXaFVa + PT ← 14-13 → FXaFVaPT

103 a

1.0 x 108 a

 

20

FXaFVai506 + PT ← 14-13 → FXaFVai506PT

103

1.0 x 108

 

21

FXaFVai306 + PT ← 14-13 → FXaFVai306PT

103

1.0 x 108

 

22

FXaFVai306/506 + PT ← 14-13 → FXaFVai306/506PT

103

1.0 x 108

 

23

FXaFVai306PT −9 → FXa + FVa1-306FVaLC + FVa307-679/709 + PT

  

0.0035

24

FXaFVai306/506PT −9 → FXa + PT + FVa1-306FVaLC + FVa307-506 + FVa507-679/709

  

0.0035

  1. a Values from previously published studies for mathematical simulations [32, 46].