Performance comparison of C-language integrators with parameter sensitivities. Performance comparison with parameter sensitivities of the C-language version odeSD
with cvodes using the automatically generated, compiled C-language right-hand side and Jacobian functions. (A) Computation times for the individual models listed in Table 2 with relative tolerance of 10−6using odeSD (white bars) and cvodes (black). (B) Average, normalized (see below) CPU times as a function of the relative numerical tolerance for odeSD relative to cvodes. In all cases, model and sensitivity equations were integrated for the time spans shown in Table 2. Performance metrics in (B) are normalized to the corresponding measures for cvodes and averaged (mean ±std.); the dashed line indicates performance equal to cvodes.