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Table 1 Common ODE integration schemes and the values that are used to approximate the polynomial in Eq. (5)

From: A specialized ODE integrator for the efficient computation of parameter sensitivities

Integrator

Nodes, explicit1

Nodes, implicit

Euler

x(t), x ̇ (t)

x(t), x ̇ (t+h)

Backward Differentiation Formula (BDF)

x ̇ (t), x(th k )

x(t), x ̇ (t+h), x(th k )

Adams-Moulton (AM)

x ̇ (t), x ̇ (t h k )

x(t), x ̇ (t+h), x ̇ (t h k )

Second-derivative rule (this work)

x(t), x ̇ (t), x ̈ (t), x ̇ (t+h), x ̈ (t+h)

  1. 1For multi-step methods, the index k = 0,−1,…,−n.