Figure 1

(A) Biochemical network for the HipBA system. A is the HipA protein; B is the HipB protein. Dimerized HipB is denoted B₂, while the complex of HipA and HipB is AB₂A. P, P’, and P” are the promoter states and M is mRNA. All chemical reactions for the simulations are given in Eq. 2; parameters are listed in Table 1. (B) Summary of the dual negative feedback structure of the model. (C) Reduced order deterministic model has a single stable equilibrium point. Nullclines for the reduced order model are plotted.