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Table 1 Chemical reaction parameters for the HipBA system

From: Modeling suggests that gene circuit architecture controls phenotypic variability in a bacterial persistence network

Reaction Reactants Products Reaction Rate Value Units Range Tested Reference
transcription P M + P α 60 hour^-1 6-600 [29, 30]
transcription P' M + P' αB2 6 hour^-1 0.6-60 [29, 30]
transcription P'' M + P'' αAB2A 6 hour^-1 0.6-60 [29, 30]
HipB binds to promoter P + B2 P' θB2 1500 hour^-1/mol 150-15,000 approximated based on [31]
HipB unbinds P' P + B2 γB2 60 hour^-1 6-600 approximated based on [31]
HipB-HipA complex binds to promoter P + AB2A P'' θAB2A 1500 hour^-1/mol 150-15,000 [31]
HipBA unbinds P'' P + AB2A γAB2A 60 hour^-1 6-600 [31]
mRNA degradation M 0 δM 6 hour^-1 0.6-60 [32]
HipB translation M M + B βB 60 mol/hr/mRNA 6-600 [29, 30]
HipA translation M M + A βA 12 mol/hr/mRNA 1.2-120 [29, 30]
HipB degradation B 0 δB 18 hour^-1 1.8-180 [21]
HipA degradation A 0 δA 1.2 hour^-1 0.12-12 [31, 32]
HipB dimerization B + B B2 βB2 60 hour^-1 6-600 assumed monomeric form to be uncommon
HipB dimer degradation B2 0 δB2 5 hour^-1 0.5-50 [21]
HipB-HipA complex association B2 + 2A AB2A μ 60 hour^-1/mol 6-600 approximated based on [31]
HipB-HipA complex dissociation AB2A B2 + 2A μR 60 hour^-1 6-600 approximated based on [31]
HipB-HipA complex degradation AB2A 0 δAB2A 1.2 hour^-1 0.12-12 [31, 32]