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Table 1 Terms and definitions used in the analysis between in silico predictions and in vivo observations

From: Genome-scale metabolic model of the fission yeast Schizosaccharomyces pombe and the reconciliation of in silico/in vivo mutant growth

Term Definition Description
True postive (TP) In silico: viable phenotype Results where the metabolic model predicts a viable phenotype and the actual phenotype is also viable
  In vivo: viable phenotype  
True negative (TN) In silico: lethal phenotype In vivo: lethal phenotype Results where the metabolic model predicts a lethal phenotype and the actual phenotype is also lethal
False positive (FP) In silico: viable phenotypeIn vivo: lethal phenotype Results where the metabolic model predicts a viable phenotype but the actual phenotype is lethal
False negative (FN) In silico: lethal phenotype In vivo: viable phenotype Results where the metabolic model predicts a lethal phenotype but the actual phenotype is viable
Overall accuracy (TP + TN)/(TP + TN + FP + FN) Percentage of correct predictions by the metabolic model
Negative prediction rate (TN)/(TN + FN) Percentage of negative predictions that are correctly predicted as lethal
Positive prediction rate (TP)/(TP + FP) Percentage of positive predictions that are correctly predicted as viable
Sensitivity (TP)/(TP + FN) Percentage of viable predictions correctly predicted as positive
Specificity (TN)/(TN + FP) Percentage of lethal predictions correctly predicted as negative