Table 5 Top 15 co-targets for countering drug resistance under ETA treatment

pgk

0.12

In Vitro essential

phosphoglycerate kinase

[55]

Rv3802c

0.25

In Vitro essential

conserved membrane protein

[55]

Rv1343c

0.37

Not Essential

lipoprotein

[65, 66]

Rv1474c

0.03

Not Essential

transcriptional regulator

Rv0481c

0.08

Not Essential

hypothetical protein

Rv2455c

0.63

Not Essential

oxidoreductase alpha subunit

accA2

0.36

In Vitro essential

acetyl-/propionyl-CoA carboxylase alpha subunit

[59]

fadD18

0.05

Not Essential

fatty-acid-CoA ligase

fadA5

0.45

Not Essential

acetyl-CoA acetyltransferase

[2]

atpB

0.46

In Vitro essential

ATP synthase A chain

[55, 67]

Rv2367c

0.28

Not Essential

hypothetical protein

Rv3355c

0.01

Not Essential

conserved hypothetical protein

Rv2199c

0.55

Not Essential

conserved membrane protein

Rv3310

1.38

Not Essential

acid phosphatase

[68]

nadC

0.59

Not Essential

nicotinate-nucleotide pyrophosphatase

[69]