Table 1 Top 10 up-regulated genes in HOS/143B model

283150

8

8.4 x 10E-6

Play roles in determining cell fates during early development

6252

7

1.1 x 10E-5

Involved in membrane trafficking in neuroendocrine cells

257019

7

1.7 x 10E-5

Structural protein essential for erythrocyte shape and mechanical properties

3205

7

1.4 x 10E-5

Transcription factor which may regulate gene expression, morphogenesis and differentiation

285

7

9.4 x 10E-6

In concert with VEGF, may serve as a permissive angiogenic signal

3875

6

1.1 x 10E-5

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells

3587

6

1.0 x 10E-5

Interferon receptor that mediates the immunosuppressive signal of IL10

7163

6

2.0 x 10E-5

Uncharacterized function, but expressed in many tumor cell lines including colon, breast, prostate, pancreas and kidney

760

6

1.8 x 10E-5

Essential for bone resorption and osteoclast differentiation

389206

6

1.2 x 10E-5

Uncharacterized function, but known to be phosphorylated upon DNA damage