Table 2 Top 10 up-regulated genes in SaOS-2/LM7 model

10763

30

1.8 x 10E-11

May play a role in the trafficking and distribution of intermediate filaments and other cell factors during cell division

256764

25

1.8 x 10E-9

Involved in enamel formation

8673

24

1.5 x 10E-10

Involved in the targeting and fusion of transport vesicles to their target membrane

143662

23

3.2 x 10E-12

May play a role in the cell adhesion to the extracellular matrix

9890

21

1.5 x 10E-10

Facilitates axonal outgrowth during development and regenerative sprouting

5787

18

1.9 x 10E-9

Plays an important role in blood vessel remodelling and angiogenesis

11197

18

5.6 x 10E-11

Binds to Wnt proteins and inhibits their activities

5801

17

4.6 x 10E-9

Sequesters protein kinases in the cytoplasm in an inactive form and releases them for activation and translocation into the nucleus

387758

17

1.5 x 10E-11

Uncharacterized

6850

16

1.0 x 10E-10

Regulates several processes including immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development