Enrichment of confident regulator predictions for ChIP binding. Plots show percentage of top ranked confident regulator predictions that had confirmed bindings by predicted regulators within 2000 base pairs of the putative target gene. Predictions were ranked by the posterior probability of (a) regulation by any single regulator; or (b) joint regulation by any two regulators. Both plots include rankings according to the marginal posterior probability of a set of regulators being active computed over all 32 models (dark blue bars), posterior probability over a restricted set of models ignoring all other TFs leaving 2 models for single regulator and 4 models for two regulators (light blue bars) as well as maximum likelihood-based baseline model (yellow bars) and the Inferelator (red bars), compared to predicting regulators uniformly at random (blue line; link probability 0.5). p-values of results statistically significantly different from random are denoted by ‘***’: p<0.001, ‘**’: p<0.01, ‘*’:p<0.05.