Figure 2

HYP scores for TNFα-treated NHBE cells. Transcriptomic data from TNFα-treated NHBE cells was scored using each scoring method (Strength, GPI, EPI, and MASS) for (a) the NF-κB-direct HYP, (b) the IKK/NF-κB signaling HYP, (c) the TNF HYP, and (d) the E2F1-direct HYP. Error bars represent the 95 % confidence interval as determined by the Uncertainty statistic, and scores that failed the Specificity criterion (Specificity p-value > 0.05; 1000 comparable HYPs) are shaded in gray.