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Figure 5 | BMC Systems Biology

Figure 5

From: Centrality-based pathway enrichment: a systematic approach for finding significant pathways dominated by key genes

Figure 5

Summary of MAPK-TRK pathway generated under in-largest reach centrality. A) Distribution of in-largest reach centrality of differential nodes in the simulated pathway. The distribution of differential nodes centralities in each simulation is assessed by maximum value, the 75th quartile, median value and minimum value; B) Distribution of in-largest reach centrality of all nodes in the real pathway; C) Histogram of simulated scores in the pathway; D) Graph view of the pathway where the size of a node is proportional to its centrality value and nodes in red represent differential nodes. In figures A and B, dots are randomly shifted by small intervals for ease of visualization. In figures A and C, the real pathway score is marked with a red line.

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