Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach

BMC Systems Biology

Table 2 Prior knowledge

Regulator	Target	Interaction	Source	Score	Reference
HapX	sreA	repression	1	0.5	[29]
HapX	AFUA_5G10610	interaction	2	0.25	[32]
HapX	mirB	activation	1,3	0.625	[32, 51]
HapX	hemA	repression	2	0.25	[32]
HapX	sdh2	repression	2	0.25	[32]
input	sreA	activation	2	0.25	[31]
input	hapX	repression	2	0.25	[32]
PacC	mirB	interaction	3	0.125	[46]
PacC	ftrA	interaction	3	0.125	[46]
PacC	hem13	interaction	3	0.125	[46]
SreA	sdh2	repression	2	0.25	[31]
SreA	hemA	repression	2	0.25	[31]
SreA	AFUA_5G10610	repression	2	0.25	[31]
SreA	hapX	repression	1,3	0.625	[31]
SreA	mirB	repression	1	0.5	[31]
SreA	ftrA	repression	1,3	0.625	[31]
SreA	sidL	repression	3	0.125	[31]
SrbA	hapX	activation	1	0.5	[37]
SrbA	ftrA	activation	1	0.5	[37]
SrbA	mirB	activation	1	0.5	[37]
SrbA	hem13	activation	1	0.5	[37]
SreA	hem13	no interaction	1	0.5	[37]

The table lists regulator-target gene interactions, the type of interaction, the source of prior knowledge, the score used and references. The second part of the table lists additional prior knowledge we exploited in order to refine the model within the second round of modelling. "Input" denotes the fact that a target gene is regulated by the external perturbation (shift from iron replete to iron depleted conditions).

ISSN: 1752-0509