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Table 2 Prior knowledge

From: Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach

Regulator Target Interaction Source Score Reference
HapX sreA repression 1 0.5 [29]
HapX AFUA_5G10610 interaction 2 0.25 [32]
HapX mirB activation 1,3 0.625 [32, 51]
HapX hemA repression 2 0.25 [32]
HapX sdh2 repression 2 0.25 [32]
input sreA activation 2 0.25 [31]
input hapX repression 2 0.25 [32]
PacC mirB interaction 3 0.125 [46]
PacC ftrA interaction 3 0.125 [46]
PacC hem13 interaction 3 0.125 [46]
SreA sdh2 repression 2 0.25 [31]
SreA hemA repression 2 0.25 [31]
SreA AFUA_5G10610 repression 2 0.25 [31]
SreA hapX repression 1,3 0.625 [31]
SreA mirB repression 1 0.5 [31]
SreA ftrA repression 1,3 0.625 [31]
SreA sidL repression 3 0.125 [31]
SrbA hapX activation 1 0.5 [37]
SrbA ftrA activation 1 0.5 [37]
SrbA mirB activation 1 0.5 [37]
SrbA hem13 activation 1 0.5 [37]
SreA hem13 no interaction 1 0.5 [37]
  1. The table lists regulator-target gene interactions, the type of interaction, the source of prior knowledge, the score used and references. The second part of the table lists additional prior knowledge we exploited in order to refine the model within the second round of modelling. "Input" denotes the fact that a target gene is regulated by the external perturbation (shift from iron replete to iron depleted conditions).