Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach

BMC Systems Biology

Table 3 Transcriptional regulators and predicted target genes

Regulator	newly predicted target genest
	Before refinement	After refinement
SreA	sreA, hem13*	sreA
HapX	hapX	hapX
PacC	pacC, hem13
SrbA	srbA, *hapX*	*srbA,hemA*

For each regulator, newly predicted target genes are shown. A target gene is counted as "newly predicted" if it was predicted by the time series data without prior knowledge, or if it was predicted by prior knowledge based on the occurrence of transcription factor binding motif (source 3) and was found to be consistent with the gene expression data. The second column of the table lists the results after refining the model. Bold genes have been validated by Northern blots [37] (before refinement) or binding to SrbA (after refinement). The interaction marked with asterix was falsified.

ISSN: 1752-0509