Gene interaction enrichment and network analysis to identify dysregulated pathways and their interactions in complex diseases

Table 1 Q-values for pathways detected by of GIENA and GSA for the P53 dataset

Pathway	Cooperation	Competition	Redundancy	Dependency	GSA
P53	0.005	0.004	0.007	0.006	<0.001
P53 hypoxia	0.016	0.004	0.016	0.006	<0.001
G1 & S phase	0.035	0.004	0.037	0.006	0.005
EPONFKB	0.043	0.004	0.041	0.023	0.040
Mitochondria	0.043	0.004	0.041	0.021	0.032
BBCELL	0.016	0.004	0.013	0.024	0.040
BAD	0.016	0.004	0.011	0.021	0.019
RAS	0.016	0.047	0.020	0.006	0.005
ASBCELL	0.005	0.005	0.005	0.021	0.040
FAS signaling	0.016	0.005	0.041	0.024	0.032
ALS	0.043	0.008	0.041	0.024	0.032
RACCYCD	0.043	0.008	0.041	0.021	0.032
Programmed cell death	0.016	0.009	0.009	0.024	0.040
FML	0.045	0.05	0.046	0.026	0.005
HSP27	0.016	0.011	0.016	0.019	0.007

ISSN: 1752-0509