Figure 2
From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells
Basal network motif controlling heterogeneous differentiation in the two master regulator paradigm. Solid green arrow: activation influence in which the activator alone can switch on the expression of the target protein. Dashed green arrow: activation influence in which the activator alone cannot switch on the expression of the target protein. Red arrow: inhibition influence. Protein name in parenthesis: possible intermediate protein for the positive feedback loop. a. Prototype Model 1: heterogeneous differentiation of TH1 and TH2. b. Prototype Model 2: heterogeneous differentiation of TH1 and TH17. c. Prototype Model 3: heterogeneous differentiation of iTReg and TH17. d. The basal network motif.