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Figure 5 | BMC Systems Biology

Figure 5

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Figure 5

Analyses of the basal motif with auto-activation relations. a. Bidirectional two-parameter bifurcation diagram with respect to primary signal S1 and polarizing signals S2 and S3 for intermediate weight of auto-activation relations (ω = 1.8). Insets show the zoomed-in view of the cusp regions of the bistable region. b. Bidirectional two-parameter bifurcation diagram with respect to primary signal S1 and polarizing signals S2 and S3 for high weight of auto-activation relations (ω = 3.2). The types of stable steady states in each region are annotated as colored circles. Adjoined circles: multistability. See Figure 1 for interpretation of the color scheme. Light blue area: bistable region governing differentiation switch. Light green area: bistable region governing reprogramming switch. Light yellow area: bistable region governing co-expression switch. c-f. Various types of heterogeneity scores are plotted for high weight of auto-activation relations (ω = 3.2). c. The heterogeneity scores with respect to XSP and YSP. d. The heterogeneity scores with respect to XSP and DP. e. The heterogeneity scores with respect to YSP and DP. f. The heterogeneity scores with respect to XSP, YSP and DP.

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