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Figure 6 | BMC Systems Biology

Figure 6

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Figure 6

Analyses of Prototype Model 1 (heterogeneous differentiation of T H 1 and T H 2 cells). a. Bidirectional two-parameter bifurcation diagram with respect to primary signal TCR and polarizing signals IL-12 and IL-4. b. Simulation results for induced differentiation. The heterogeneity scores with respect to T-bet single-positive phenotype and GATA3 single-positive phenotype are shown. c. Same legend as Panel A. The GATA-3 auto-activation relation is blocked in the model. d. Same legend as Panel B. The GATA-3 auto-activation relation is blocked in the model. In Panels A and C: Adjoined circles: multistability. Blue circle: naïve phenotype. Green circle: T-bet single-positive phenotype. Red circle: GATA3 single positive phenotype. Yellow: DP phenotype.

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