Figure 7
From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells
Analyses of Prototype Model 2 (heterogeneous differentiation of T H 1 and T H 17 cells). a. Two-parameter bifurcation diagram with respect to primary signal TCR and polarizing signal IL-23 + IL1. b. Simulation results for induced differentiation. The heterogeneity scores with respect to T-bet single-positive phenotype and DP phenotype are shown. c. Two-parameter bifurcation diagram with respect to primary signal TCR and polarizing signal TGF-β + IL-6. d. Simulation results for induced differentiation. Heterogeneity scores with respect to T-bet single-positive phenotype and RORγt single-positive phenotype are shown. In Panels A and C: Adjoined circles: multistability. Blue circle: naïve phenotype. Green circle: T-bet single-positive phenotype. Red circle: RORγt single-positive phenotype. Yellow: DP phenotype.