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Table 1 Signaling components in basal motif and their corresponding biological components in prototype models

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Model Generic signaling component Corresponding biological component
Prototype 1 Primary signal (S1) TCR signal
Prototype 1 Polarizing signal 1 (S2) Exogenous IL-12
Prototype 1 Polarizing signal 2 (S3) Exogenous IL-4
Prototype 1 Master regulator 1 (X) T-bet
Prototype 1 Master regulator 2 (Y) GATA3
Prototype 2 Primary signal (S1) TCR signal
Prototype 2 Polarizing signal 1 (S3-1) Exogenous IL-23 + IL-1 signal
Prototype 2 Polarizing signal 2 (S3-2) Exogenous TGF-β + IL-6 signal
Prototype 2 Master regulator 1 (X) T-bet
Prototype 2 Master regulator 2 (Y) RORγt
Prototype 3 Primary signal (S1) TCR + Exogenous TGF-β signal
Prototype 3 Polarizing signal 1 (S2) Exogenous ATRA/IL-2 signal
Prototype 3 Polarizing signal 2 (S3) Exogenous IL-6 signal
Prototype 3 Master regulator 1 (X) Foxp3
Prototype 3 Master regulator 2 (Y) RORγt