Table 1 Signaling components in basal motif and their corresponding biological components in prototype models
From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells
Model | Generic signaling component | Corresponding biological component |
|---|---|---|
Prototype 1 | Primary signal (S1) | TCR signal |
Prototype 1 | Polarizing signal 1 (S2) | Exogenous IL-12 |
Prototype 1 | Polarizing signal 2 (S3) | Exogenous IL-4 |
Prototype 1 | Master regulator 1 (X) | T-bet |
Prototype 1 | Master regulator 2 (Y) | GATA3 |
Prototype 2 | Primary signal (S1) | TCR signal |
Prototype 2 | Polarizing signal 1 (S3-1) | Exogenous IL-23 + IL-1 signal |
Prototype 2 | Polarizing signal 2 (S3-2) | Exogenous TGF-β + IL-6 signal |
Prototype 2 | Master regulator 1 (X) | T-bet |
Prototype 2 | Master regulator 2 (Y) | RORγt |
Prototype 3 | Primary signal (S1) | TCR + Exogenous TGF-β signal |
Prototype 3 | Polarizing signal 1 (S2) | Exogenous ATRA/IL-2 signal |
Prototype 3 | Polarizing signal 2 (S3) | Exogenous IL-6 signal |
Prototype 3 | Master regulator 1 (X) | Foxp3 |
Prototype 3 | Master regulator 2 (Y) | RORγt |