Table 2 Evidences for molecular influences in prototype models

Prototype 1

TCR signal upregulates T-bet expression

[34]

Prototype 1

TCR signal upregulates GATA3 expression

[35]

Prototype 1

IL-12 signal upregulates T-bet expressionin the presence of TCR signal

[34]

Prototype 1

IL-4 signal upregulates GATA3 expressionin the presence of TCR signal

[18, 36]

Prototype 1

T-bet inhibits GATA3 expression

[37]

Prototype 1

GATA3 inhibits T-bet expression

[38]

Prototype 1

T-bet promotes its own expression

[39]

Prototype 1

GATA3 promotes its own expression

[40]

Prototype 2

TCR signal upregulates T-bet expression

[34]

Prototype 2

TCR signal upregulates RORγt expression in the presence of TGF-β

[41, 42]

Prototype 2

IL-23 + IL-1 signal upregulates RORγt expressionin the presence of TCR signal

[17]

Prototype 2

TGF-β signal upregulates RORγt expressionin the presence of TCR signal

[17]

Prototype 2

TGF-β signal downregulates T-bet expression

[43]

Prototype 2

T-bet inhibits RORγt expression

[44]

Prototype 2

RORγt inhibits T-bet expression

[45]

Prototype 2

T-bet promotes its own expression

[39]

Prototype 2

RORγt promotes its own expression

[11, 46]

Prototype 3

TCR signal upregulates Foxp3 expressionin the presence of TGF-β

[41, 42]

Prototype 3

TCR signal upregulates RORγt expressionin the presence of TGF-β

[41, 42]

Prototype 3

TGF-β signal upregulates Foxp3 expressionin the presence of TCR signal

[41, 42]

Prototype 3

TGF-β signal upregulates RORγt expressionin the presence of TCR signal

[41, 42]

Prototype 3

IL-6 upregulates RORγt expression

[47]

Prototype 3

IL-6 downregulates Foxp3 expression

[47]

Prototype 3

ATRA/IL-2 upregulates Foxp3 expression

[48, 49]

Prototype 3

ATRA/IL-2 downregulates RORγt expression

[48, 49]

Prototype 3

Foxp3 inhibits RORγt expression

[50]

Prototype 3

RORγt inhibits Foxp3 expression

[51]

Prototype 3

Foxp3 promotes its own expression

[11]

Prototype 3

RORγt promotes its own expression

[11, 46]