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Table 2 Evidences for molecular influences in prototype models

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Model Molecular Influence Evidence
Prototype 1 TCR signal upregulates T-bet expression [34]
Prototype 1 TCR signal upregulates GATA3 expression [35]
Prototype 1 IL-12 signal upregulates T-bet expressionin the presence of TCR signal [34]
Prototype 1 IL-4 signal upregulates GATA3 expressionin the presence of TCR signal [18, 36]
Prototype 1 T-bet inhibits GATA3 expression [37]
Prototype 1 GATA3 inhibits T-bet expression [38]
Prototype 1 T-bet promotes its own expression [39]
Prototype 1 GATA3 promotes its own expression [40]
Prototype 2 TCR signal upregulates T-bet expression [34]
Prototype 2 TCR signal upregulates RORγt expression in the presence of TGF-β [41, 42]
Prototype 2 IL-23 + IL-1 signal upregulates RORγt expressionin the presence of TCR signal [17]
Prototype 2 TGF-β signal upregulates RORγt expressionin the presence of TCR signal [17]
Prototype 2 TGF-β signal downregulates T-bet expression [43]
Prototype 2 T-bet inhibits RORγt expression [44]
Prototype 2 RORγt inhibits T-bet expression [45]
Prototype 2 T-bet promotes its own expression [39]
Prototype 2 RORγt promotes its own expression [11, 46]
Prototype 3 TCR signal upregulates Foxp3 expressionin the presence of TGF-β [41, 42]
Prototype 3 TCR signal upregulates RORγt expressionin the presence of TGF-β [41, 42]
Prototype 3 TGF-β signal upregulates Foxp3 expressionin the presence of TCR signal [41, 42]
Prototype 3 TGF-β signal upregulates RORγt expressionin the presence of TCR signal [41, 42]
Prototype 3 IL-6 upregulates RORγt expression [47]
Prototype 3 IL-6 downregulates Foxp3 expression [47]
Prototype 3 ATRA/IL-2 upregulates Foxp3 expression [48, 49]
Prototype 3 ATRA/IL-2 downregulates RORγt expression [48, 49]
Prototype 3 Foxp3 inhibits RORγt expression [50]
Prototype 3 RORγt inhibits Foxp3 expression [51]
Prototype 3 Foxp3 promotes its own expression [11]
Prototype 3 RORγt promotes its own expression [11, 46]