Table 3 Features of three bistable switches obtained with the basal motif
From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells
Bistable switch | Phenotypic transition controlled by the switch | Underlying positive feedback loops | Type of related heterogeneous differentiation |
|---|---|---|---|
Differentiation | Naïve ⇔ XSP or YSP | Auto-activation | NA |
Reprogramming | XSP ⇔ YSP | Created by mutual inhibition and enhanced by auto-activation | Type 1 |
Co-expression | XSP or YSP ⇔ DP | Auto-activation | Type 2 |