From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells
Conditions of differentiation induction | Induced cell population | Evidence |
---|---|---|
TCR signal alone | The cell population is dominated by the TH1 cells | [17] |
TCR signal and IL-23 + IL-1 signal | Heterogeneous differentiation of T-bet+RORγt- cells and T-bet+RORγt+ cells. | [17] |
TCR signal and TGF-β + IL-6 signal | The cell population is dominated by T-bet-RORγt+ cells | [17] |
Lowering TCR signal after differentiation | Reprogramming from T-bet+RORγt+ cells to T-bet+RORγt- cells | Prediction |
TCR signal and low dose of TGF-β + IL-6 (≈0.4 unit) | Heterogeneous differentiation of TH1 and TH17 cells | Prediction |
Knocking out T-bet genes and inducing with TCR signal | Homogeneous differentiation of T-bet-RORγt+ cells with either TGF-β signal or IL-23 + IL-1 signal | [17] |