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Table 5 Summary of simulation results of Prototype Model 2

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Conditions of differentiation induction

Induced cell population

Evidence

TCR signal alone

The cell population is dominated by the TH1 cells

[17]

TCR signal and IL-23 + IL-1 signal

Heterogeneous differentiation of T-bet+RORγt- cells and T-bet+RORγt+ cells.

[17]

TCR signal and TGF-β + IL-6 signal

The cell population is dominated by T-bet-RORγt+ cells

[17]

Lowering TCR signal after differentiation

Reprogramming from T-bet+RORγt+ cells to T-bet+RORγt- cells

Prediction

TCR signal and low dose of TGF-β + IL-6 (≈0.4 unit)

Heterogeneous differentiation of TH1 and TH17 cells

Prediction

Knocking out T-bet genes and inducing with TCR signal

Homogeneous differentiation of T-bet-RORγt+ cells with either TGF-β signal or IL-23 + IL-1 signal

[17]