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Table 6 Summary of simulation results of Prototype Model 3

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Conditions of differentiation induction Induced cell population Evidence
Intermediate TGF-β + TCR signal (1.5-2 units) Heterogeneous differentiation of Foxp3+RORγt-, Foxp3-RORγt+ and Foxp3+RORγt+ cells [15]
High TGF-β + TCR signal (2.5 units) Heterogeneous differentiation of Foxp3-RORγt+ and Foxp3+RORγt+ cells [16]
Low-Intermediate TGF-β + TCR signal (1–2 units) and IL-6 signal Heterogeneous differentiation of Foxp3-RORγt+ and Foxp3+RORγt+ cells [15]
Low TGF-β + TCR signal (1–1.5 units) Heterogeneous differentiation of Foxp3+RORγt-, Foxp3-RORγt+ cells Prediction
Low-intermediate level of TGF-β + TCR signal (1–2 units) and IL-2 or ATRA Homogeneous differentiation of Foxp3+RORγt- cells Prediction
High TGF-β + TCR signal (2.5 units) and IL-2 or ATRA Heterogeneous differentiation of Foxp3+RORγt- and Foxp3+RORγt+ cells Prediction