A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

BMC Systems Biology

Table 6 Summary of simulation results of Prototype Model 3

Conditions of differentiation induction	Induced cell population	Evidence
Intermediate TGF-β + TCR signal (1.5-2 units)	Heterogeneous differentiation of Foxp3⁺RORγt^-, Foxp3^-RORγt⁺ and Foxp3⁺RORγt⁺ cells	[15]
High TGF-β + TCR signal (2.5 units)	Heterogeneous differentiation of Foxp3^-RORγt⁺ and Foxp3⁺RORγt⁺ cells	[16]
Low-Intermediate TGF-β + TCR signal (1–2 units) and IL-6 signal	Heterogeneous differentiation of Foxp3^-RORγt⁺ and Foxp3⁺RORγt⁺ cells	[15]
Low TGF-β + TCR signal (1–1.5 units)	Heterogeneous differentiation of Foxp3⁺RORγt^-, Foxp3^-RORγt⁺ cells	Prediction
Low-intermediate level of TGF-β + TCR signal (1–2 units) and IL-2 or ATRA	Homogeneous differentiation of Foxp3⁺RORγt^- cells	Prediction
High TGF-β + TCR signal (2.5 units) and IL-2 or ATRA	Heterogeneous differentiation of Foxp3⁺RORγt^- and Foxp3⁺RORγt⁺ cells	Prediction

ISSN: 1752-0509