Evolvability of feed-forward loop architecture biases its abundance in transcription networks

BMC Systems Biology

Table 3 Transition probabilities for single mutations C1-C4

	G ⁺	G ^-	P ⁺ T ⁺	P ^- T ^-	P ⁺ T ^-	P ^- T ⁺
C1
G ⁺	0.251	0	0.008	0	0	0
G ^-	0	0.329	0	0	0.003	0
P ⁺ T ⁺	0.015	0	0.180	0.013	0	0
P ^- T ^-	0	0	0.015	0.157	0	0
P ⁺ T ^-	0	0.0049	0	0	0.031	0
P ^- T ⁺	0	0	0	0	0	0
C2
G ⁺	0	0	0.007	0	0	0
G ^-	0	0.82	0	0	0.007	0
P ⁺ T ⁺	0.008	0	0.022	0.001	0	0
P ^- T ^-	0	0	0.043	0.039	0	0
P ⁺ T ^-	0	0.007	0	0	0.039	0
P ^- T ⁺	0	0	0	0	0	0
C3
G ⁺	0.317	0	0.008	0	0	0
G ^-	0	0.242	0	0	0.026	0
P ⁺ T ⁺	0.023	0	0.030	0	0	0
P ^- T ^-	0	0	0	0	0	0
P ⁺ T ^-	0	0.043	0	0	0.174	0.046
P ^- T ⁺	0	0	0	0	0.046	0.151
C4
G ⁺	0.815	0	0.019	0	0	0
G ^-	0	0	0	0	0.019	0
P ⁺ T ⁺	0	0	0.037	0	0	0
P ^- T ^-	0	0	0	0	0	0
P ⁺ T ^-	0	0.037	0	0	0.037	0
P ^- T ⁺	0	0	0	0	0	0.037

Table 3,4,5 and 6 list the transition probabilities between functions for every motif and its respective function probability distribution. The values are obtained from numerical simulation.

ISSN: 1752-0509