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Table 2 Parameters for new features added to model

From: Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia

Model Parameter Value Comment Reference
Kf-IC4 0.001 uM-1.s-1 Forward rate of IC4 binding PP1α --
Kr-IC4 0.0005 s-1 Reverse rate of IC4 binding PP1α --
Kf-IP3R1-Ct 10 uM-1.s-1 Forward rate of IP3R1 C-terminal binding PP1α --
Kr-IP3R1-Ct 0.0005 s-1 Reverse rate of IP3R1 C-terminal binding PP1α --
Kf-mutant-IC4 20 uM-1.s-1 Forward rate of IC4 binding mAtaxin --
Kr-mutant-IC4 0.0005 s-1 Reverse rate of IC4 binding mAtaxin --
Kf-mutant-IP3R1-Ct 20 uM-1.s-1 Forward rate of IP3R1 C-terminal binding mAtaxin --
Kr-mutant-IP3R1-Ct 0.0005 s-1 Reverse rate of IP3R1 C-terminal binding mAtaxin --
mAtaxin_init variable Mutant Ataxin PolyQ Protein --
PP1α_init 1 uM Directly binds tip of IP3R1 C-terminal [43]
IP3R1-Ct_init 1 uM Tip of IP3R1 C-terminal --
IC4_init 2 uM Competitively inhibits PP1α binding [43]
IC-G2736X_init 2 uM Associates with polyQ region [52]
IC10_init variable Competitively inhibits polyQ binding [53]