Table 2 Parameters for new features added to model
Model Parameter | Value | Comment | Reference |
|---|---|---|---|
Kf-IC4 | 0.001 uM-1.s-1 | Forward rate of IC4 binding PP1α | -- |
Kr-IC4 | 0.0005 s-1 | Reverse rate of IC4 binding PP1α | -- |
Kf-IP3R1-Ct | 10 uM-1.s-1 | Forward rate of IP3R1 C-terminal binding PP1α | -- |
Kr-IP3R1-Ct | 0.0005 s-1 | Reverse rate of IP3R1 C-terminal binding PP1α | -- |
Kf-mutant-IC4 | 20 uM-1.s-1 | Forward rate of IC4 binding mAtaxin | -- |
Kr-mutant-IC4 | 0.0005 s-1 | Reverse rate of IC4 binding mAtaxin | -- |
Kf-mutant-IP3R1-Ct | 20 uM-1.s-1 | Forward rate of IP3R1 C-terminal binding mAtaxin | -- |
Kr-mutant-IP3R1-Ct | 0.0005 s-1 | Reverse rate of IP3R1 C-terminal binding mAtaxin | -- |
mAtaxin_init | variable | Mutant Ataxin PolyQ Protein | -- |
PP1α_init | 1 uM | Directly binds tip of IP3R1 C-terminal | [43] |
IP3R1-Ct_init | 1 uM | Tip of IP3R1 C-terminal | -- |
IC4_init | 2 uM | Competitively inhibits PP1α binding | [43] |
IC-G2736X_init | 2 uM | Associates with polyQ region | [52] |
IC10_init | variable | Competitively inhibits polyQ binding | [53] |