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Table 3 Suggested use of ICpeptides relevant to this study

From: Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia

ICpeptide

Base pairs

Minimal binding region of target

Use suggested by this study

Reference

IC4

Q2714-A2749

R2731-G2736

in vivo competitive inhibition of PP1α

(Tang et al., 2003b,

   

with reduced levels of IP3R1

Tu et al., 2004)

IC-G2736X

D2590-G2736

F2627-G2736

in vitro/vivo competitive inhibition of mutant Ataxin

(Tang et al., 2009)

   

with supersensitive IP3R1

 

IC10

F2627-A2749

F2627-G2736

possible alternative to IC-G2726X

(Tang et al., 2009)