Functional model from node scores and edge scores. Shown is the functional module based on node and edge scores from the dESTs, calculated on a subnetwork based on edge scores from the ESTs (A). Circles depict nodes with positive scores, squares with negative score. The coloring of the nodes shows the Z statistic from the Umbrella test (positive: red, negative: green). Positive scores indicate an umbrella shape and negative scores an inverse umbrella shape of the time courses. For the edges the colors indicate the differential abundance of the enzyme (red), presence (orange) or absence (green) of the enzyme responsible for the metabolic reaction. Representative metabolites with a significant trend are shown in the right panel (B). The time points are depicted equally spaced for better visualization.