Figure 2

Simulation results of the sAPPα and sAPPβ end products. Simulation results of our multi-compartmental model (lines) for the various APP products are shown together with the actual data points obtained in biochemical experiments by Schmidt and colleagues[14]. The total amount of products (black line) is the sum of the products produced in monomer (red line) and in dimer processing (green line) pathways. In the absence of SORLA, the products produced in the dimer processing pathways more closely resemble the total amount of sAPPα (A) and sAPPβ (B). With SORLA, the amounts of sAPPα and sAPPβ that are produced in dimer processing are significantly reduced as compared to those in monomer processing (C, D).