Figure 8
From: Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease
Switch from preferred dimer-to-monomer processing. Simulations of the influence of SORLA on APP processing into sAPPα (A, C) and sAPPβ (B, D) are shown (where SORLATot = 2.43 x 105 fmol). Total amount of products produced from both processing (black line) as well as the products produced from dimer (green line) and monomer (red line) processing are indicated for each simulation. A switch from preferred dimer-to-monomer processing is seen at 25% of SORLATot for α-secretase (A) and at 3% of SORLATot for β-secretase (B). The amount of product obtained from ‘red’ monomer is greater than that of ‘green’ dimer is observed at 145% of SORLATot for α-secretase (C) and at 150% of SORLATot for β-secretase (D).