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Figure 5 | BMC Systems Biology

Figure 5

From: A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations

Figure 5

 In silico  Simulations of Perturbations: (A) Wild-type behaviour. (B) Expression of Dbf4 reduced to 10% of nominal. (C) Expression of Cdc6 reduced to 10% of nominal. (D) Total abundance of Cdt1 reduced to 10% of nominal. Perturbations of Cdc6 and Dbf4 had a significant impact on replicative efficiency, as evidence by a reduced abundance of activated replication forks (FORK). In contrast, a similar reduction in Cdt1 levels had much less impact.

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