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Figure 7 | BMC Systems Biology

Figure 7

From: A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations

Figure 7

 In silico  perturbations to the consensus model agree with reported  in vivo  cell cycle defects. (A) Wildtype behaviour. (B) Reduction of the rate of Dbf4-MCM association (k12) to 50% of the nominal value. (C) Reduction of the rate of Cdc45 interaction with the pre-RC (k13) to 50% of the nominal value. In both cases, a decrease in the abundance of the FORK species indicates a defect in DNA replication.

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