Figure 7

 In silico  perturbations to the consensus model agree with reported  in vivo  cell cycle defects. (A) Wildtype behaviour. (B) Reduction of the rate of Dbf4-MCM association (k₁₂) to 50% of the nominal value. (C) Reduction of the rate of Cdc45 interaction with the pre-RC (k₁₃) to 50% of the nominal value. In both cases, a decrease in the abundance of the FORK species indicates a defect in DNA replication.