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Figure 3 | BMC Systems Biology

Figure 3

From: Different designs of kinase-phosphatase interactions and phosphatase sequestration shapes the robustness and signal flow in the MAPK cascade

Figure 3

Robustness of the output MK-PP of four models built using elementary mass action kinetics (K2) to perturbations in their kinases and phosphatases concentrations, for fixed and variable signal strengths. (A) Robustness of the output (MK-PP) in the four models for random variations in the concentrations of their kinases, for both unsequestrated (USEQ) and phosphatase sequestrated (PSEQ) conditions are shown when the models were subjected to fixed signal of identical strength. The concentration variation of the kinases was in the range of 0.1 – 10 times the reference concentration values. (B) Robustness of the output (MK-PP) in the four models for random variations in the concentrations of their phosphatases, for both USEQ and PSEQ conditions are shown when the models were subjected to fixed signal of identical strength. The concentration variation of the phosphatases was in the range of 0.1 – 10 times the reference concentration values. (C) Robustness of the output (MK-PP) in the four models for random variations in the concentrations of their kinases as well as input signal strength for both USEQ and PSEQ conditions is shown. Range of concentration variation of the kinases was 0.1 – 10 times the reference concentration values. (D) Robustness of the output (MK-PP) in the four models for random variations in the concentrations of their phosphatases as well as input signal strength for both USEQ and PSEQ conditions is shown. Range of concentration variation of the phosphatases was 0.1 – 10 times the reference concentration values. In the figures (A)-(D), red bar represents PSEQ condition and blue bar represents USEQ condition.

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