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Figure 5 | BMC Systems Biology

Figure 5

From: Different designs of kinase-phosphatase interactions and phosphatase sequestration shapes the robustness and signal flow in the MAPK cascade

Figure 5

An implicit negative feedback loop from Phos2 to MKKK layer in the system M4K2 and M4K2_QSS. (A) Kinetics of MKKK-P in M4K2 for a low (5 nM) and a high (1000 nM) Phos2 concentration is shown for unsequestrated (USEQ) condition. (B) Kinetics of MKKK-P in M4K2 for a low (5 nM) and a high (1000 nM) Phos2 concentration is shown for phosphatase sequestrated (PSEQ) condition. (C) Kinetics of MKKK-P in M4K2_QSS for a low (5 nM) and a high (1000 nM) Phos2 concentration is shown for unsequestrated (USEQ) condition. (D) Kinetics of MKKK-P in M4K2_ QSS for a low (5 nM) and a high (1000 nM) Phos2 concentration is shown for phosphatase sequestrated (PSEQ) condition. (E) Steady state phosphorylation amplitude of MKKK-P at various concentrations of Phos2 in M4K2. Steady state MKKK-P amplitude in PSEQ and USEQ conditions are given with blue and green dotted lines. (F) Steady state phosphorylation amplitude of MKKK-P at various concentrations of Phos2 in M4K2_ QSS . Steady state MKKK-P amplitude in PSEQ and USEQ conditions are given with blue and green dotted lines.

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