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Figure 2 | BMC Systems Biology

Figure 2

From: An investigation of spatial signal transduction in cellular networks

Figure 2

Response of the coherent feedforward module. An example of the (A) gradient signal input and the (B) localized signal input used in the analysis is shown (as a function of the domain postition). In this and other simulations the graded signal has a cosine variation and is of the form S = a + bcosθ. The localized signal is of the form a + Aexp(xx o )/α. The module is subjected to a (C) gradient signal input and a (D) localized signal input and the response is shown for either when none of the elements are diffusible (solid line with circles) or when the X pathway (solid line) or the Y pathway (dashed line) is highly diffusible. The scenario where pathway X is stronger than pathway Y is shown here. In each case the response qualitatively mirrors the signal. When X diffuses, the spatial variation of the response is weaker than when Y diffuses. In both these cases, the response element exhibits weaker spatial variation when compared to the non-diffusible case.

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