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Figure 4 | BMC Systems Biology

Figure 4

From: An investigation of spatial signal transduction in cellular networks

Figure 4

Response of the positive feedback module. This module is simulated with a (A) gradient signal and a (B) localized signal input and the effect of the feedback strength is analyzed for non-diffusible species and a highly diffusible feedback element. (A) Ris shown for (non-diffusible case) k yx = 0.5 (solid line) and 2.0 (solid line with x markers) and (diffusible case) k yx = 0.5 (dashed line) and 2.0 (solid line with circles). (B) Ris shown for (the non-diffusible case) k yx = 1.0 (solid line) and (the diffusible case) k yx = 1.0 (dashed line). The response qualitatively mirrors the signal. As the feedback constant k yx increases, the total concentration of the response increases everywhere. When the feedback element is highly diffusible, the spatial profile of Rshows weaker spatial variation.

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