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Table 1 Optimisation of the coefficient of variation of phospho-Hsp27 particle numbers

From: Biochemical fluctuations, optimisation and the linear noise approximation

Reactions Changes
(no constraints)
Changes
(constraints)
complex + MKK6 ↔ complex_MKK6
complex_MKK6 → complex + MKK6P
MKK6_phosphatase + MKK6P ↔ Ppase_MKK6P ~
Ppase_MKK6P → MKK6_phosphatase + MKK6
complex + MKK3 ↔ complex_MKK3
complex_MKK3 → complex + MKK3P
MKK3_phosphatase + MKK3P ↔ Ppase_MKK3P
Ppase_MKK3P → MKK3_phosphatase + MKK3
MKK6P + p38 ↔ MKK6P_p38
MKK6P_p38 → MKK6P + p38P
MKK3P + p38 ↔ MKK3P_p38
MKK3P_p38 → MKK3P + p38P
p38_phosphatase + p38P ↔ Ppase_38P
Ppase_p38P → p38_phosphatase + p38
  1. Optimisation of the coefficient of variation of phospho-Hsp27 particle numbers with regards to all 21 reaction parameters of the listed reactions ([LPS]0 = 1 ng/ml). "Changes (no constraints)" means that the coefficient was optimised without any further constraints, whereas "Changes (constrained)" means that during optimisation the phospho-Hsp27 particle number was constrained in the optimisation to stay below the limit of 4.65 million particles. "" ("") denotes an increase (decrease) in the forward rate and a decrease (increase) in the reverse rate, in case of a reversible reaction. "" means that both forward and reaction rates are increased and "~" means that the optimisation led to no clear change