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Table 1 Effect of parameter α on the performance of ION

From: Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks

K

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

0.99

1%

0.75

0.84

0.78

0.78

0.78

0.80

0.80

0.78

0.80

0.76

0.69

5%

0.65

0.70

0.72

0.73

0.73

0.74

0.74

0.74

0.73

0.71

0.67

10%

0.62

0.66

0.65

0.66

0.65

0.65

0.64

0.64

0.63

0.61

0.61

15%

0.56

0.58

0.59

0.58

0.58

0.58

0.58

0.58

0.57

0.57

0.54

20%

0.51

0.52

0.52

0.53

0.55

0.54

0.54

0.53

0.52

0.51

0.48

25%

0.47

0.47

0.48

0.49

0.50

0.50

0.48

0.48

0.48

0.46

0.43

  1. The table shows the effect of parameter α on the performance of ION. Column ‘K’ represents top K percent of ranked proteins. Column 2 to 11 represents prediction accuracy of ION in each top percentage of ranked proteins by setting different values of α, ranging from 0 to 0.99.