Figure 4

Test set prediction results from the global NPLSR metamodelling of the mammalian circadian clock model. A) Results from the test set validation of the inverse metamodelling. Correlation coefficient (R²)-values from the global NPLSR test set prediction of the parameters from the state variable trajectories are shown, using 19 factors in the global NPLSR model. B) Results from the test set validation of the classical metamodelling. R²-values from the global NPLSR test set prediction of the state variable trajectories from the parameters are shown, using 8 factors in the global NPLSR model.