Skip to main content

Table 1 Description and range of the parameters varied in the mammalian circadian clock model simulations

From: Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models

Parameter name Unit Description Minimum value Level step size Maximum value
v mB nMh-1 Maximum rate of Bmal1 mRNA degradation 0.02 0.05 0.38
v mC nMh-1 Maximum rate of Cry mRNA degradation 0.95 0.08 1.54
v mP nMh-1 Maximum rate of Per mRNA degradation 0.98 0.16 2.09
v dPCN nMh-1 Maximum rate of degradation of nuclear phosphorylated Per-Cry complex 0.99 0.02 1.14
v dIN nMh-1 Maximum rate of degradation of nuclear Per-Cry-Clock-Bmal1 complex 0.08 0.21 1.52
k 1 h-1 Rate constant for entry of the Per-Cry complex into the nucleus 0.08 0.21 1.52
k 3 nM-1 h-1 Rate constant for the formation of the Per-Cry complex 0.08 0.21 1.52
k 5 h-1 Rate constant for entry of the Bmal1 protein into the nucleus 0.27 0.02 0.41
k 7 nM-1 h-1 Rate constant for the formation of the inactive Per-Cry-Clock-Bmal1 complex 0.05 0.13 0.95
\