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Table 1 Description and range of the parameters varied in the mammalian circadian clock model simulations

From: Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models

Parameter name

Unit

Description

Minimum value

Level step size

Maximum value

v mB

nMh-1

Maximum rate of Bmal1 mRNA degradation

0.02

0.05

0.38

v mC

nMh-1

Maximum rate of Cry mRNA degradation

0.95

0.08

1.54

v mP

nMh-1

Maximum rate of Per mRNA degradation

0.98

0.16

2.09

v dPCN

nMh-1

Maximum rate of degradation of nuclear phosphorylated Per-Cry complex

0.99

0.02

1.14

v dIN

nMh-1

Maximum rate of degradation of nuclear Per-Cry-Clock-Bmal1 complex

0.08

0.21

1.52

k 1

h-1

Rate constant for entry of the Per-Cry complex into the nucleus

0.08

0.21

1.52

k 3

nM-1 h-1

Rate constant for the formation of the Per-Cry complex

0.08

0.21

1.52

k 5

h-1

Rate constant for entry of the Bmal1 protein into the nucleus

0.27

0.02

0.41

k 7

nM-1 h-1

Rate constant for the formation of the inactive Per-Cry-Clock-Bmal1 complex

0.05

0.13

0.95