Parameter name | Unit | Description | Minimum value | Level step size | Maximum value |
---|---|---|---|---|---|
v mB | nMh-1 | Maximum rate of Bmal1 mRNA degradation | 0.02 | 0.05 | 0.38 |
v mC | nMh-1 | Maximum rate of Cry mRNA degradation | 0.95 | 0.08 | 1.54 |
v mP | nMh-1 | Maximum rate of Per mRNA degradation | 0.98 | 0.16 | 2.09 |
v dPCN | nMh-1 | Maximum rate of degradation of nuclear phosphorylated Per-Cry complex | 0.99 | 0.02 | 1.14 |
v dIN | nMh-1 | Maximum rate of degradation of nuclear Per-Cry-Clock-Bmal1 complex | 0.08 | 0.21 | 1.52 |
k 1 | h-1 | Rate constant for entry of the Per-Cry complex into the nucleus | 0.08 | 0.21 | 1.52 |
k 3 | nM-1 h-1 | Rate constant for the formation of the Per-Cry complex | 0.08 | 0.21 | 1.52 |
k 5 | h-1 | Rate constant for entry of the Bmal1 protein into the nucleus | 0.27 | 0.02 | 0.41 |
k 7 | nM-1 h-1 | Rate constant for the formation of the inactive Per-Cry-Clock-Bmal1 complex | 0.05 | 0.13 | 0.95 |