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Table 1 Comparison with multiple E. coli gene essentiality studies

From: Characterizing criticality of proteins by systems dynamics: Escherichia coli central carbon metabolism as a working example

Protein

Gene

Criticality

Flux-sum

Keio collection

Genetic footprinting

PEC database

PGK

pgk

Critical

 

GAPDH

gapA

Critical

 

ENO

eno

Critical

 

ALDO

fbaA

Critical

PGI

pgi

Uncritical

PK

pykF

Uncritical

PGM

pgm

Uncritical

Ru5P

rpe

Critical

 

 

G1PAT

glgC

Uncritical

  1. Our characterizations of protein criticality (Col 3) are compared with multiple gene essentiality studies (Col 5-7) besides the validations through flux-sum (Col 4).
  2. Note: "√" means this evidence supports the characterization of criticality