TY - JOUR AU - Zhang, Wei AU - Zou, Xiufen PY - 2012 DA - 2012/07/16 TI - Synchronization ability of coupled cell-cycle oscillators in changing environments JO - BMC Systems Biology SP - S13 VL - 6 IS - 1 AB - The biochemical oscillator that controls periodic events during the Xenopus embryonic cell cycle is centered on the activity of CDKs, and the cell cycle is driven by a protein circuit that is centered on the cyclin-dependent protein kinase CDK1 and the anaphase-promoting complex (APC). Many studies have been conducted to confirm that the interactions in the cell cycle can produce oscillations and predict behaviors such as synchronization, but much less is known about how the various elaborations and collective behavior of the basic oscillators can affect the robustness of the system. Therefore, in this study, we investigate and model a multi-cell system of the Xenopus embryonic cell cycle oscillators that are coupled through a common complex protein, and then analyze their synchronization ability under four different external stimuli, including a constant input signal, a square-wave periodic signal, a sinusoidal signal and a noise signal. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-6-S1-S13 DO - 10.1186/1752-0509-6-S1-S13 ID - Zhang2012 ER -