TY - JOUR AU - Dai, Chao AU - Li, Wenyuan AU - Liu, Juan AU - Zhou, Xianghong Jasmine PY - 2012 DA - 2012/07/16 TI - Integrating many co-splicing networks to reconstruct splicing regulatory modules JO - BMC Systems Biology SP - S17 VL - 6 IS - 1 AB - Alternative splicing is a ubiquitous gene regulatory mechanism that dramatically increases the complexity of the proteome. However, the mechanism for regulating alternative splicing is poorly understood, and study of coordinated splicing regulation has been limited to individual cases. To study genome-wide splicing regulation, we integrate many human RNA-seq datasets to identify splicing module, which we define as a set of cassette exons co-regulated by the same splicing factors. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-6-S1-S17 DO - 10.1186/1752-0509-6-S1-S17 ID - Dai2012 ER -