Figure 1

The drug cocktail network. A node represents a drug and an edge denotes an effective combination consisting of the two drugs linked by the edge. The hub drugs that have more than 6 neighbors are colored in red. The size of each node approximates its degree, the width of each edge approximates the therapeutic similarity (see equation 3) between the two drugs linked by the edge, and a grey edge means that the two drugs linked by that edge have completely different therapeutic effects. The numbers in panel 1-6 represent the top six largest child networks from the drug cocktail network.