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Table 1 The proportions of enhancers that underwent selection based on mouse-rat alignments (neutral reference: fourfold degenerate sites)

From: Natural selection drives rapid evolution of mouse embryonic heart enhancers

  Total Under selectiona Positively selectedb Under selectiona/Total Positively selectedb/Under selectiona Positively selectedb/Total
HT 2554 875 360 34.25% 41.14% 14.09%
FB 1253 595 67 47.48% 11.26% 5.34%
MB 1311 521 101 39.74% 19.38% 7.70%
LB 2570 1037 212 40.35% 20.44% 8.24%
  1. FB: forebrain; MB: midbrain; LB: limb; HT: heart.
  2. aA significantly unequal proportion of substituted sites were observed between enhancers and the fourfold degenerate sites of the neighboring gene by Fisher's exact test.
  3. bEnhancers that underwent selection and had a higher substitution rate than the fourfold degenerate sites of the neighboring gene.