Unique, high-confidence, novel predicted human complexes. (a) Number of complexes predicted and number of proteins covered. (b) Semantic coherence of predicted complexes. (a) Number of human complexes predicted and number of proteins covered, using the five weighting approaches and the COMBINED clustering strategy. SWC generates more novel complexes that cover a greater number of proteins. (b) BP, CC, and MF semantic coherence of the predicted complexes and the reference complexes CORUM. SWC's complexes have higher BP, CC, and MF coherence compared to the other weighting approaches (p < 0.05 for all, p < 0.1 for CC coherence vs NOWEI), but the CORUM complexes have higher BP and CC coherence.