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Figure 1 | BMC Systems Biology

Figure 1

From: MISCORE: a new scoring function for characterizing DNA regulatory motifs in promoter sequences

Figure 1

Correlation between the over-representation and the background rareness. ORS r scores for the functional models M t , the random models M r q , and the conserved models M c q for q = 1, 2, 3, . . ., 1000 are plotted for each dataset with 200bp and 500bp promoters in the left and in the right column, respectively. Threshold θ = R(M t ) + std(M t )λ, λ = 0.0 is used. The figure depicts a rareness interpretable visualization through the statistical over-representation property of the functional motifs by showing that, the ORS r (M r ) scores are found distant from the ORS r (M t ) scores for all cases which implies that the random models have close to zero chance of being over-represented with comparison to the true models. In addition to this, the ORS r (M t ) scores are found to be mostly rare with comparison to the ORS r (M c ) scores, i.e., these non-functional conserved models have a rare chance of having better over-representation scores than the true models, for most of the datasets.

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