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Table 2 Power comparison under two different scenario

From: Statistical aspects of omics data analysis using the random compound covariate

n cen. Scenarios 1 Scenarios 2
   SRC B SC B SRC W SC W SRC B SC B SRC W SC W
Strong effect: β= [β1, β2, ..., β30]T = [1, 1, ..., 1]T    
50 10% 0.757 0.742 0.675 0.650 0.600 0.599 0.723 0.692
  30% 0.624 0.580 0.536 0.490 0.480 0.422 0.546 0.505
  50% 0.448 0.350 0.381 0.312 0.350 0.250 0.359 0.294
75 10% 0.960 0.956 0.907 0.902 0.876 0.870 0.944 0.942
  30% 0.883 0.864 0.828 0.766 0.783 0.771 0.875 0.822
  50% 0.758 0.626 0.690 0.526 0.607 0.494 0.694 0.580
100 10% 0.998 0.997 0.985 0.982 0.974 0.973 0.996 0.995
  30% 0.982 0.974 0.948 0.917 0.940 0.905 0.966 0.955
  50% 0.928 0.846 0.868 0.730 0.806 0.695 0.883 0.802
Low effect: β= [β1, β2, ..., β30]T = [0.5, 0.5, ..., 0.5]T    
50 10% 0.666 0.625 0.594 0.576 0.266 0.242 0.326 0.305
  30% 0.498 0.487 0.440 0.430 0.206 0.165 0.224 0.214
  50% 0.362 0.285 0.328 0.244 0.144 0.122 0.162 0.124
75 10% 0.930 0.924 0.859 0.850 0.492 0.466 0.574 0.570
  30% 0.824 0.756 0.756 0.688 0.370 0.325 0.432 0.421
  50% 0.642 0.553 0.571 0.469 0.263 0.206 0.312 0.224
100 10% 0.992 0.990 0.964 0.950 0.662 0.654 0.796 0.792
  30% 0.959 0.944 0.918 0.850 0.558 0.505 0.652 0.594
  50% 0.852 0.760 0.802 0.654 0.412 0.319 0.472 0.370
  1. We compared the power under each method SRC B /SRC W and SC B /SC W . The first scenario considers 30 disease related genes. The second scenario considers 30 disease related genes, with the other 27 genes considered no effect.